Immunotherapy of human tumour xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction.

@article{Modjtahedi1993ImmunotherapyOH,
  title={Immunotherapy of human tumour xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction.},
  author={Helmout Modjtahedi and Suzanne A. Eccles and Gary Box and Jennifer M. Styles and Christopher J. Dean},
  journal={British Journal of Cancer},
  year={1993},
  volume={67},
  pages={254 - 261}
}
Athymic mice bearing xenografts of human tumours that overexpress the receptor (EGFR) for EGF and TGF alpha have been used to evaluate the therapeutic potential of three new rat monoclonal antibodies (mAbs) directed against two distinct epitopes on the extracellular domain of the human EGFR. The antibodies, ICR16 (IgG2a), ICR62 (IgG2b) and ICR64 (IgG1), have been shown (Modjtahedi et al., 1993) to be potent inhibitors of the growth in vitro of a number of human squamous cell carcinomas because… CONTINUE READING