Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA.

@article{Sheets2003ImmunotherapyOH,
  title={Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA.},
  author={Ellen E. Sheets and Robert G Urban and Christopher P Crum and Mary Lynne Hedley and Joseph A Politch and Michael A. Gold and Laila I. Muderspach and Geoffrey A Cole and Peggy A. Crowley-Nowick},
  journal={American journal of obstetrics and gynecology},
  year={2003},
  volume={188 4},
  pages={916-26}
}
OBJECTIVE The purpose of this study was to evaluate the safety of the administration of a bacterial expression plasmid encoding a 13 amino acid sequence that is highly homologous with human papillomavirus E7 within poly (lactide-co-glycolide) microparticles (ZYC101) in women with HLA A2+ antigen and persistent cervical intraepithelial neoplasia grade 2/3 and human papillomavirus 16. STUDY DESIGN Fifteen women entered an institutional review board-approved dose-escalating phase I study with… CONTINUE READING