Immunotherapy of cancer through targeting of minor histocompatibility antigens.

  title={Immunotherapy of cancer through targeting of minor histocompatibility antigens.},
  author={Lothar Hambach and Els Goulmy},
  journal={Current opinion in immunology},
  volume={17 2},
Minor histocompatibility antigens are allogeneic targets of T-cell mediated graft-versus-tumour effects following allogeneic stem cell transplantation. Recent research has identified several minor histocompatibility antigens as tumour proteins and has also disclosed their unique properties in both the induction and the effector phase of graft-versus-tumour effects. Targeting tumour-specific minor histocompatibility antigens by adoptive immunotherapy will battle against tumour tolerance and… CONTINUE READING
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