Immunotherapy of CD30-expressing lymphoma using a highly stable ssDNA aptamer.

@article{Parekh2013ImmunotherapyOC,
  title={Immunotherapy of CD30-expressing lymphoma using a highly stable ssDNA aptamer.},
  author={Parag Parekh and Sanchit Kamble and Nianxi Zhao and Zihua Zeng and Bryce Patrick Portier and Youli Zu},
  journal={Biomaterials},
  year={2013},
  volume={34 35},
  pages={8909-17}
}
CD30 is highly expressed on Hodgkins lymphoma and anaplastic large cell lymphoma, making it an attractive target for therapy. We describe the generation of serum-stabilized ssDNA aptamers that bind CD30 via a hybrid SELEX methodology. The selected aptamer bound CD30 with high affinity and specificity. Further optimization of the aptamer led to a short, truncated variant with a 50-fold higher affinity than its longer counterpart. The multivalent aptamer was able to induce oligomerization of CD30… CONTINUE READING
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