Immunotherapy of Advanced Breast Cancer With a

  title={Immunotherapy of Advanced Breast Cancer With a},
  author={Adriana Carr and Edmundo Rodrı́guez and D Arango and Rolando Camacho and Marta Os{\'o}rio and Mariano R Gabri and Guido Carrillo and Zolidina Vald{\'e}s and Yanı́n Bebelagua and Rolando P{\'e}rez and Luis E. Fern{\'a}ndez},
Purpose: A heterophilic ganglioside cancer vaccine was developed by combining NeuGcGM3 with the outer membrane protein complex of Neisseria meningitidis to form very small size proteoliposomes (VSSP). A phase I clinical trial was performed to determine safety and immunogenicity of this vaccine. Patients and Methods: Stage III to IV breast cancer patients received up to 15 (200 g) doses of the vaccine by intramuscular injection. The first five doses (induction phase) were given at 2-week… CONTINUE READING
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