Immunotherapy for the treatment of prostate cancer

@article{Lorenzo2011ImmunotherapyFT,
  title={Immunotherapy for the treatment of prostate cancer},
  author={G. Lorenzo and C. Buonerba and P. Kantoff},
  journal={Nature Reviews Clinical Oncology},
  year={2011},
  volume={8},
  pages={551-561}
}
Failure of immune surveillance has a prominent role in tumorigenesis. Cancerous cells can evade T-cell responses to tumor-associated antigens by multiple mechanisms. Active immunotherapy aims to stimulate the immune response against cancer cells. Unlike normal prostate tissue, prostate cancer is not ignored by the immune system, as shown by the presence of tumor infiltrating lymphocytes. This characteristic renders prostate cancer particularly suitable for immunotherapy. The existence of well… Expand
95 Citations

Paper Mentions

Interventional Clinical Trial
This study is designed to evaluate multiple clinical hypotheses and mechanistically-defined combinations to evaluate the safety and efficacy of immunotherapy combinations in… Expand
ConditionsMetastatic Castration-resistant Prostate Cancer
InterventionDevice, Drug, Radiation
Potentiating prostate cancer immunotherapy with oncolytic viruses
  • 24
Cell-mediated immunotherapy for hepatocellular carcinoma
  • 1
  • PDF
Immunotherapy for Prostate Cancer Enters Its Golden Age
  • 10
  • PDF
Dendritic cell trafficking in tumor-bearing mice
  • 4
The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development
  • P. Corn
  • Medicine
  • Cancer management and research
  • 2012
  • 51
  • Highly Influenced
  • PDF
Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures.
  • 19
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 75 REFERENCES
T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer
  • M. Mercader, B. Bodner, +10 authors E. Kwon
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
  • 325
  • PDF
Therapeutic vaccines for prostate cancer.
  • 46
  • PDF
Prostate cancer as a model for tumour immunotherapy
  • C. Drake
  • Medicine
  • Nature Reviews Immunology
  • 2010
  • 284
  • PDF
Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF.
  • 233
  • Highly Influential
  • PDF
Clinical safety of a viral vector based prostate cancer vaccine strategy.
  • 114
Phase I study with an autologous tumor cell vaccine for locally advanced or metastatic prostate cancer.
  • M. Berger, F. Kreutz, J. L. Horst, A. Baldi, W. Koff
  • Medicine
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2007
  • 19
  • PDF
...
1
2
3
4
5
...