Immunotherapy for the treatment of prostate cancer

@article{Lorenzo2011ImmunotherapyFT,
  title={Immunotherapy for the treatment of prostate cancer},
  author={G. Lorenzo and C. Buonerba and P. W. Kantoff},
  journal={Nature Reviews Clinical Oncology},
  year={2011},
  volume={8},
  pages={551-561}
}
  • G. Lorenzo, C. Buonerba, P. W. Kantoff
  • Published 2011
  • Medicine
  • Nature Reviews Clinical Oncology
  • Failure of immune surveillance has a prominent role in tumorigenesis. Cancerous cells can evade T-cell responses to tumor-associated antigens by multiple mechanisms. Active immunotherapy aims to stimulate the immune response against cancer cells. Unlike normal prostate tissue, prostate cancer is not ignored by the immune system, as shown by the presence of tumor infiltrating lymphocytes. This characteristic renders prostate cancer particularly suitable for immunotherapy. The existence of well… CONTINUE READING
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    References

    SHOWING 1-10 OF 75 REFERENCES
    T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer
    • M. Mercader, B. Bodner, +10 authors E. Kwon
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2001
    • 324
    • PDF
    Therapeutic vaccines for prostate cancer.
    • 46
    • PDF
    Prostate cancer as a model for tumour immunotherapy
    • C. Drake
    • Medicine
    • Nature Reviews Immunology
    • 2010
    • 282
    • PDF
    Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF.
    • 233
    • Highly Influential
    • PDF
    Clinical safety of a viral vector based prostate cancer vaccine strategy.
    • 114
    Phase I study with an autologous tumor cell vaccine for locally advanced or metastatic prostate cancer.
    • 19
    • PDF