Immunotherapy for recurrent pregnancy loss: analysis of results from clinical trials.

@article{Coulam1996ImmunotherapyFR,
  title={Immunotherapy for recurrent pregnancy loss: analysis of results from clinical trials.},
  author={Carolyn B Coulam and Mary Sue Stephenson and John J. Stern and David A. Clark},
  journal={American journal of reproductive immunology},
  year={1996},
  volume={35 4},
  pages={352-9}
}
PROBLEM Up to 80% of unexplained recurrent spontaneous abortions (RSA) are thought to have an immunologic mechanism. Yet clinical trials using immunotherapy to treat women experiencing RSA have low treatment effects. The present study was undertaken to explain the low treatment effects. METHODS Results of clinical trials using allogeneic leukocyte immunization and intravenous (IV) immunoglobulin (Ig) are compared. The mechanisms of pregnancy loss are reviewed in light of data on frequency of… CONTINUE READING
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