Immunotherapy for cancer: synthetic carbohydrate-based vaccines.

@article{Buskas2009ImmunotherapyFC,
  title={Immunotherapy for cancer: synthetic carbohydrate-based vaccines.},
  author={Therese Buskas and Pamela S Thompson and Geert-Jan Boons},
  journal={Chemical communications},
  year={2009},
  volume={36},
  pages={5335-49}
}
Aberrant glycosylation of glycoproteins and glycolipids of cancer cells, which correlates with poor survival rates, is being exploited for the development of immunotherapies for cancer. In particular, advances in the knowledge of cooperation between the innate and adaptive system combined with the implementation of efficient synthetic methods for assembly of oligosaccharides and glycopeptides is providing avenues for the rationale design of vaccine candidates. In this respect, fully synthetic… CONTINUE READING
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