Immunotherapy for Acne Vulgaris: Current Status and Future Directions

  title={Immunotherapy for Acne Vulgaris: Current Status and Future Directions},
  author={Thierry Simonart},
  journal={American Journal of Clinical Dermatology},
  • T. Simonart
  • Published 10 September 2013
  • Biology
  • American Journal of Clinical Dermatology
There is a high unmet clinical need for new and better treatments in acne vulgaris. Propionibacterium acnes has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity, keratinocytes and sebaceous glands of the pilosebaceous follicle. The role of P. acnes in acne confers legitimacy on the possible benefits of immunization-based approaches, which may represent a solution for limiting the development of antibiotic-resistant P. acnes. Various immunization… 


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“Yuvanpidika : A modern and Ayurvedic perspective.”

Acne vulgaris is a chronic skin disease of the pilo-sebaceous unit and develops due to blockages in the skin's hair follicles. It is characterized by blackheads or whiteheads, pimples, oily skin, and

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Vaccination Targeting a Surface Sialidase of P. acnes: Implication for New Treatment of Acne Vulgaris

An acne vaccine targeting a cell wall-anchored sialidase of Propionibacterium acnes is created and indicated that acne vaccines open novel therapeutic avenues for acne vulgaris and other P. acnes-associated diseases.

Acne vaccines: therapeutic option for the treatment of acne vulgaris?

  • Jenny Kim
  • Biology, Medicine
    The Journal of investigative dermatology
  • 2008
Identifying immune modulators that attenuate inflammatory responses against P. acnes and the inhibition of bacterial growth may lead to novel avenues of immunologic intervention.

Vaccine therapy for P. acnes-associated diseases.

The data strongly show that immunization of ICR mice with the vaccines provides in vivo protective immunity against P. acnes challenge and decreases P. Acnes-induced elevation of cytokine production.

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The aim of this viewpoint is to provide some hypotheses about the potential function of AMP in the pathogenesis of acne and to discuss potential AMP‐based therapies for the treatment of acne.

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[Skin reactions to antigens of propionibacterium acnes in patients with acne vulgaris treated with autovaccine].

  • E. Załuga
  • Medicine, Biology
    Annales Academiae Medicae Stetinensis
  • 1998
It was concluded that specific antibodies generated by the autovaccine and directed against the strain of Propionibacterium acnes of the patient may reduce the intensity of delayed-type reactions in some cases of acne, as previously reported for tularemia and tuberculosis.

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  • T. Simonart
  • Medicine
    American Journal of Clinical Dermatology
  • 2012
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