Immunotherapy for Acne Vulgaris: Current Status and Future Directions

@article{Simonart2013ImmunotherapyFA,
  title={Immunotherapy for Acne Vulgaris: Current Status and Future Directions},
  author={Thierry Simonart},
  journal={American Journal of Clinical Dermatology},
  year={2013},
  volume={14},
  pages={429-435}
}
  • T. Simonart
  • Published 10 September 2013
  • Biology
  • American Journal of Clinical Dermatology
There is a high unmet clinical need for new and better treatments in acne vulgaris. Propionibacterium acnes has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity, keratinocytes and sebaceous glands of the pilosebaceous follicle. The role of P. acnes in acne confers legitimacy on the possible benefits of immunization-based approaches, which may represent a solution for limiting the development of antibiotic-resistant P. acnes. Various immunization… 

PATHOGENETIC MECHANISM OF ACNE-COUPLED INFLAMMATION

It was found that P. acnes initiates TLR2-mediated innate immune reaction both at early and late stages of developing dermatosis, which results in upregulated immune genes including those encoding cytokines and chemokines recruiting immune cells.

Update on etiopathogenesis and treatment of Acne

A new armamentarium of drugs for the treatment of acne, including anti-androgens, insulin-like growth factor-1 inhibitors, peroxisome proliferator-activated receptor-modulators, acetylcholine inhibitors, topical retinoic acid metabolism-blocking agents, vitamin D analogues, antimicrobial peptides, interleukin-1β blockers and immunotherapy are some of the novel treatment options.

Acne and Its Variants in Special Populations

It is important for medical practitioners to familiarize themselves with these differing presentations and sequelae in specific populations to provide adequate evaluations and treatment regimens.

Assessment of Serum Level of SIRT1 in Patients with Acne Vulgaris

Serum Sirtuin1 levels are diminished in patients with serious AV contrasted with patients with gentle, moderate and controls, presumably mirror the part of SIRT1 in the pathogenesis of AV.

Updates on the use of vaccines in dermatological conditions

A review of the different vaccines available for use in dermatological diseases and those under development for future potential use, using the availability of published research online through available databases.

Insights into the mechanism of Cymbopogan martinii essential oil in topical therapy of acne vulgaris.

Investigation of the essential oil of Cymbopogan martinii (palmarosa oil; PRO) as a potential topical therapy in acne vulgaris found it to be safe for topical application and may prove useful as a natural topical agent in the management of acne.

“Yuvanpidika : A modern and Ayurvedic perspective.”

Acne vulgaris is a chronic skin disease of the pilo-sebaceous unit and develops due to blockages in the skin's hair follicles. It is characterized by blackheads or whiteheads, pimples, oily skin, and

Analytical tools and evaluation strategies for nanostructured lipid carrier-based topical delivery systems

An in-depth account of analytical tools and evaluation procedures under one roof of nanostructured lipid carriers, proven for their potential to foster the therapeutic modalities applicable to cutaneous disorders are furnished.

References

SHOWING 1-10 OF 62 REFERENCES

Vaccination Targeting a Surface Sialidase of P. acnes: Implication for New Treatment of Acne Vulgaris

An acne vaccine targeting a cell wall-anchored sialidase of Propionibacterium acnes is created and indicated that acne vaccines open novel therapeutic avenues for acne vulgaris and other P. acnes-associated diseases.

Acne vaccines: therapeutic option for the treatment of acne vulgaris?

  • Jenny Kim
  • Biology, Medicine
    The Journal of investigative dermatology
  • 2008
Identifying immune modulators that attenuate inflammatory responses against P. acnes and the inhibition of bacterial growth may lead to novel avenues of immunologic intervention.

Vaccine therapy for P. acnes-associated diseases.

The data strongly show that immunization of ICR mice with the vaccines provides in vivo protective immunity against P. acnes challenge and decreases P. Acnes-induced elevation of cytokine production.

New developments in our understanding of acne pathogenesis and treatment

A summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years is provided.

What is the role of antimicrobial peptides (AMP) in acne vulgaris?

The aim of this viewpoint is to provide some hypotheses about the potential function of AMP in the pathogenesis of acne and to discuss potential AMP‐based therapies for the treatment of acne.

Propionibacterium acnes: an update on its role in the pathogenesis of acne

Novel therapies should target molecules implicated in the activation of innate immunity, including toll‐like receptors, protease‐activated receptors and topical antimicrobial peptides; the latter may be an alternative to topical antibiotics and thus a solution for limiting bacterial resistance induced by topical macrolides.

Propionibacterium acnes vaccination induces regulatory T cells and Th1 immune responses and improves mouse atopic dermatitis

Vaccination with low dose of P. acnes successfully prevented clinical manifestations in the skin of AD mice associated with systemic and cutaneous increased expression of Th1‐type cytokines but without suppression of Th2 cytokines.

[Skin reactions to antigens of propionibacterium acnes in patients with acne vulgaris treated with autovaccine].

  • E. Załuga
  • Medicine, Biology
    Annales Academiae Medicae Stetinensis
  • 1998
It was concluded that specific antibodies generated by the autovaccine and directed against the strain of Propionibacterium acnes of the patient may reduce the intensity of delayed-type reactions in some cases of acne, as previously reported for tularemia and tuberculosis.

Newer Approaches to the Treatment of Acne Vulgaris

  • T. Simonart
  • Medicine
    American Journal of Clinical Dermatology
  • 2012
The purpose of this paper is to discuss the therapies available for acne and their latest developments, including new treatment strategies, and their rationale and likely place in treatment.
...