Immunotherapy I: Cytokine gene transfer strategies

@article{Colombo1997ImmunotherapyIC,
  title={Immunotherapy I: Cytokine gene transfer strategies},
  author={Mario P Colombo and Guido Forni},
  journal={Cancer and Metastasis Reviews},
  year={1997},
  volume={16},
  pages={421-432}
}
The cytokine approach to gene therapy of cancer stems from early studies of direct, repeated injection of recombinant cytokines at the tumor site, and extension of the bystander effect that enables a few cytokine gene transduced cells in a tumor to bring about its total destruction. This effect can be extended through the immune system, since cytokine-activated regression of a small mass of tumor cells can afford systemic protection. Transduced cells used as a vaccine provide a local… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 72 REFERENCES

Hypotoxic tumor death and modulation of endothelial adhesion molecules in the regression of G-CSF transduced tumors

  • MP Colombo, L Lombardi, +4 authors A Stopacciaro
  • Am J Pathol
  • 1996
1 Excerpt

Similar Papers

Loading similar papers…