Immunotherapeutic potential of monoclonal antibodies againstPseudomonas aeruginosa protein F

  title={Immunotherapeutic potential of monoclonal antibodies againstPseudomonas aeruginosa protein F},
  author={Robert E. W. Hancock and Lucy M Mutharia and E. C. A. Mouat},
  journal={European Journal of Clinical Microbiology},
To unambiguously demonstrate the immunotherapeutic potential of outer membrane porin protein F fromPseudomonas aeruginosa, a series of monoclonal antibodies have been isolated and demonstrated to be specific for protein F by Western blotting procedures. The antibodies recognize a surface-exposed antigenic site that is conserved on allPseudomonas aeruginosa strains tested to date. One of these monoclonal antibodies named MA4-4 resulted in passive protection against subsequent infections… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 11 citations


Publications referenced by this paper.
Showing 1-10 of 13 references

Quantitation and identification of antibodies to the outer membrane proteins of Pseudomonas aeruginosa in the sera of cystic fibrosis patients

  • J. S. Lain, L. M. Mutharia, +5 authors J. W. Costerton
  • Journal of Infectious Diseases
  • 1984

Use of a purified outer membrane protein F ( porin ) preparation of Pseudomonas aeruginosa as a protective vaccine in mice

  • D. D. Stieritz, L A. Holder
  • Infection and Immunity
  • 1984

Immunogeni - city of Pseudomonas aeruginosa outer membrane proteins examined by crossed immunoelectrophoreis

  • R. E. W. Hancock, L. M. Mutharia, L. Chart, R. P. Darveau, D. P. Speert, G. B. Pier
  • Infection and Immunity
  • 1983

Serological characterization of Pseudomonas aeruginosa

  • B. Lanyi, T. Bergan
  • Methods in Microbiology
  • 1978