Immunotherapeutic potential in guinea-pig tumor model of deoxyribonucleic acid from Mycobacterium bovis BCG complexed with poly-L-lysine and carboxymethylcellulose.

@article{Kataoka1990ImmunotherapeuticPI,
  title={Immunotherapeutic potential in guinea-pig tumor model of deoxyribonucleic acid from Mycobacterium bovis BCG complexed with poly-L-lysine and carboxymethylcellulose.},
  author={Tetsuro Kataoka and S Yamamoto and T. Yamamoto and Tohru Tokunaga},
  journal={Japanese journal of medical science \& biology},
  year={1990},
  volume={43 5},
  pages={
          171-82
        }
}
In vivo antitumor activity of a deoxyribonucleic acid fraction obtained from Mycobacterium bovis BCG (named MY-1) increased when it was complexed with poly-L-lysine (poly LL) solubilized by addition of carboxymethylcellulose (CMC). The complex of MY-1 and poly LL/CMC induced interferon in vivo at a low dose of MY-1 which alone exerted no IFN induction. With Line 10 hepatoma (L10) which is syngeneic with strain 2 guinea pigs, it was demonstrated that repeated intralesional injections of the… 
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References

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In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG.
TLDR
Antitumor activities of MY-1 were also abolished if the animals were pretreated with anti-asialo GM1 antiserum or carrageenan, suggesting that the activities can be ascribed mainly to activated NK cells.
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity.
TLDR
A fraction extracted from Mycobacterium bovis strain BCG, which was composed of 70% DNA, 28.0% RNA, 1.3% protein, 0.20% glucose, and 0.1% lipid, was found to possess strong antitumor activity, suggesting that the DNA from BCG possessed strong antitUMor activity under certain conditions.
Immunotherapeutic potential in murine tumor models of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose.
TLDR
The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose eradicated established experimental and spontaneous pulmonary metastases and suggest that the systemic Administration of poly(I,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.
Immunomodulatory effects in mice of polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose.
TLDR
The results indicate that poly(I,C)-LC has considerable potential as an immunotherapeutic agent, with the ability not only to induce macrophage and NK cell activation but also to stimulate specific cytotoxic T-lymphocytes.
STUDIES ON THE HETEROLOGOUS IMMUNOGENICITY OF A METHANOL-INSOLUBLE FRACTION OF ATTENUATED TUBERCLE BACILLI (BCG)
Small quantities of the non-toxic residue of phenol-killed, acetone-washed, and methanol-extracted tubercle bacilli of the BCG strain conferred a high degree of resistance on mice against otherwise
[Phase I clinical study of MY-1, a new biological response modifier].
TLDR
After MY-1 treatment, enhanced PPD skin reaction and increased OKT4/OKT8 ratio in peripheral lymphocyte subsets were observed which were statistically significant especially at a dose level of 3 mg, the optimal dose and schedule for phase II clinical study were considered.
Mycobacterial RNA. A comparison with intact mycobacteria for suppression of murine tumor growth.
TLDR
The host's immunological system is a necessary component for inhibition of tumors by the authors' test materials since there is no tumor suppression in immunologically impaired mice.
Isolation and properties of a macromolecular, water-soluble, immuno-adjuvant fraction from the cell wall of Mycobacterium smegmatis.
TLDR
The water-soluble material has a stronger adjuvant activity than equal amounts of whole bacteria, cell walls, or wax D, and seems to be the first well-defined, water- soluble, adjUvant-active fraction isolated from Mycobacteria.
BACILLUS CALMETTE‐GUÉRIN CONTACT IMMUNOTHERAPY OF LOCAL AND METASTATIC DEPOSITS OF RAT TUMORS *
TLDR
Evidence indicates that local activation of host macrophages is probably the essential effector mechanism of adjuvant contact therapy, and this treatment is effective in hosts that lack full immunocompetence, making it still feasible in immunosuppressed patients.
A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates.
TLDR
A comlex of polyriboinosinic-polyribocytidylic acid with poly-L-lysine and carboxymethylcellulose with significant levels of serum interferon in monkeys and chimpanzees under conditions in which poly I-poly C itself induces no interferons is prepared.
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