Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand

@article{Wu2007ImmunotherapeuticAO,
  title={Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand},
  author={Christina C. N. Wu and Tomoko Hayashi and K. Takabayashi and M. Sabet and D. Smee and Donald D Guiney and H. Cottam and D. Carson},
  journal={Proceedings of the National Academy of Sciences},
  year={2007},
  volume={104},
  pages={3990 - 3995}
}
The immunotherapeutic activity of Toll-like receptor (TLR) activators has been difficult to exploit because of side effects related to the release and systemic dispersion of proinflammatory cytokines. To overcome this barrier, we have synthesized a versatile TLR7 agonist, 4-[6-amino-8-hydroxy-2-(2-methoxyethoxy)purin-9-ylmethyl]benzaldehyde (UC-1V150), bearing a free aldehyde that could be coupled to many different auxiliary chemical entities through a linker molecule with a hydrazine or amino… Expand
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