Immunosurveillance of senescent cells: the bright side of the senescence program

  title={Immunosurveillance of senescent cells: the bright side of the senescence program},
  author={Adi Sagiv and Valery Krizhanovsky},
Cellular senescence, a state of irreversible cell cycle arrest, is a robust mechanism used to mediate tumor suppression and control the tissue damage response following short-term insults. In addition, the senescence associated-secretory phenotype (SASP), one of the most profound characteristics of the senescence program, facilitates the immunosurveillance of senescent cells. The SASP includes many chemokines, cytokines and adhesion molecules that can recruit and activate distinct immune cells… 

Cellular senescence: Immunosurveillance and future immunotherapy

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  • A. Lujambio
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2016
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