Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis.

@article{Watson2006ImmunosurveillanceIA,
  title={Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis.},
  author={Nicholas Watson and Judith M. Ramage and Zahra Madjd and Ian Spendlove and Ian O. Ellis and John Howard Scholefield and Lindy Durrant},
  journal={International journal of cancer},
  year={2006},
  volume={118 1},
  pages={6-10}
}
Many colorectal tumors lose or downregulate cell surface expression of MHC class I molecules conferring resistance to T-cell-mediated attack. It has been suggested that this phenomenon is due to in vivo immune-tumor interactions. However, evidence of the impact of MHC class I loss on outcomes from colorectal cancer is scarce. In our study of more than 450 colorectal cancers in tissue microarray format, we have shown that both high levels of MHC class I expression and absent MHC class I… CONTINUE READING

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