Immunosuppressive treatment protects against angiotensin II-induced renal damage.

@article{Muller2002ImmunosuppressiveTP,
  title={Immunosuppressive treatment protects against angiotensin II-induced renal damage.},
  author={Dominik N. Muller and Erdenechimeg Shagdarsuren and J Park and Ralf Dechend and Eero M. A. Mervaala and Franziska Hampich and Anette Fiebeler and Xinsheng Ju and Piet Finckenberg and Juergen Theuer and Christiane Viedt and Joerg Kreuzer and Harald Heidecke and Hermann Haller and Martin Zenke and Friedrich C. Luft},
  journal={The American journal of pathology},
  year={2002},
  volume={161 5},
  pages={1679-93}
}
Angiotensin (Ang) II promotes renal infiltration by immunocompetent cells in double-transgenic rats (dTGRs) harboring both human renin and angiotensinogen genes. To elucidate disease mechanisms, we investigated whether or not dexamethasone (DEXA) immunosuppression ameliorates renal damage. Untreated dTGRs developed hypertension, renal damage, and 50% mortality at 7 weeks. DEXA reduced albuminuria, renal fibrosis, vascular reactive oxygen stress, and prevented mortality, independent of blood… CONTINUE READING
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