Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide.

@article{Houssiau2002ImmunosuppressiveTI,
  title={Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide.},
  author={Fr{\'e}d{\'e}ric A. Houssiau and Carlos Silva Vasconcelos and David D D'Cruz and G D Sebastiani and Enrique de Ramon Garrido Ed and Maria Giovanna Danieli and Daniel Abramovicz and Daniel Blockmans and Alessandro Mathieu and Haner Direskeneli and Mauro Galeazzi and Ahmet G{\"u}l and Yair M Levy and Peter Petera and Rajko Popovi{\'c} and Radmila R. Petrovic and Renato A Sinico and Roberto Cattaneo and J Font and Genevi{\`e}ve Depresseux and J Cosyns and Ricard Cervera},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 8},
  pages={2121-31}
}
OBJECTIVE Glomerulonephritis is a severe manifestation of systemic lupus erythematosus (SLE) that is usually treated with an extended course of intravenous (IV) cyclophosphamide (CYC). Given the side effects of this regimen, we evaluated the efficacy and the toxicity of a course of low-dose IV CYC prescribed as a remission-inducing treatment, followed by azathioprine (AZA) as a remission-maintaining treatment. METHODS In this multicenter, prospective clinical trial (the Euro-Lupus Nephritis… CONTINUE READING
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