Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma.

@article{Marshall2004ImmunosuppressiveRT,
  title={Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma.},
  author={Neil A. Marshall and Linsey E Christie and Laura R Munro and Dominic J. Culligan and Peter W. Johnston and R N Barker and Mark Armstrong John Vickers},
  journal={Blood},
  year={2004},
  volume={103 5},
  pages={1755-62}
}
Although immunosuppression has long been recognized in Hodgkin lymphoma (HL), the underlying basis for the lack of an effective immune response against the tumor remains unclear. The aim was to test our hypothesis that regulatory T cells dominate involved lymph nodes. The approach was to assay CD4+ T-cell function in HL-infiltrating lymphocytes (HLILs) and paired peripheral blood mononuclear cells (PBMCs) of 24 patients. Strikingly, unlike PBMCs, HLILs were anergic to stimulation with mitogen… CONTINUE READING

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Regulatory T cells in transplantation tolerance

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