Immunosuppressive properties of electrophoretically "slow" and "fast" form alpha 2-macroglobulin. Effects on cell-mediated cytotoxicity and (allo-) antigen-induced T cell proliferation.

@article{Petersen1989ImmunosuppressivePO,
  title={Immunosuppressive properties of electrophoretically "slow" and "fast" form alpha 2-macroglobulin. Effects on cell-mediated cytotoxicity and (allo-) antigen-induced T cell proliferation.},
  author={Claus Munck Petersen and E Ejlersen and Soren K. Moestrup and Poul Henning Jensen and Ole Christian Sand and Lars Sottrup-Jensen},
  journal={Journal of immunology},
  year={1989},
  volume={142 2},
  pages={629-35}
}
Lymphokine activated killer cell lysis of K562 cells was inhibited by alpha 2-macroglobulin (alpha 2M), soybean trypsin inhibitor, and alpha 1-proteinase inhibitor. In serum free medium 2 mg/ml alpha 2M suppressed target cell lysis in a 4-h cytotoxic assay with about 40%. Suppression was dose and time dependent. Cytotoxicity was unaffected by alpha 2M… CONTINUE READING