• Biology, Medicine
  • Published in Journal of virology 1990

Immunosuppressive function of hepatitis B antigens in vitro: role of endoribonuclease V as one potential trans inactivator for cytokines in macrophages and human hepatoma cells.

@article{Jochum1990ImmunosuppressiveFO,
  title={Immunosuppressive function of hepatitis B antigens in vitro: role of endoribonuclease V as one potential trans inactivator for cytokines in macrophages and human hepatoma cells.},
  author={Charbanou Jochum and Richard Voth and Siegbert Rossol and K. H. Meyer zum B{\"u}schenfelde and Georg Hess and H. Will and Heinz C Schr{\"o}der and Renate Steffen and Werner E. G. Mueller},
  journal={Journal of virology},
  year={1990},
  volume={64 5},
  pages={
          1956-63
        }
}
The mRNAs of transiently expressed cytokine genes contain AUUUA-rich sequences in the 3' untranslated regions. In order to examine whether the AU-specific endoribonuclease V (EC 3.1.27.8) described previously by us transinactivates those mRNA species, we introduced a 51-nucleotide ATTTA sequence from tumor necrosis factor into the 3' untranslated region of beta-globin gene. Transcripts of that construct, synthesized in vitro, were prone to endoribonuclease V digestion at those AU-rich sequences… CONTINUE READING

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