Immunosuppressive efficacy of mycophenolate mofetil when compared with azathioprine and mizoribine against peripheral lymphocytes from renal transplant recipients.

@article{Sugiyama2005ImmunosuppressiveEO,
  title={Immunosuppressive efficacy of mycophenolate mofetil when compared with azathioprine and mizoribine against peripheral lymphocytes from renal transplant recipients.},
  author={Kentaro Sugiyama and Hiroshi Satoh and Kazuhide Saito and Kota Takahashi and Noriko Saito and Toshihiko Hirano},
  journal={Transplant international : official journal of the European Society for Organ Transplantation},
  year={2005},
  volume={18 5},
  pages={590-5}
}
Mycophenolate mofetil is currently used instead of azathioprine in clinical transplantation. However, comparative studies for the immunosuppressive potency of anti-metabolites used for organ transplantation have not been well documented. We compared the pharmacological efficacy of mycophenolic acid (MPA), 6-meraputopurine (6-MP), and mizoribine (MZ) for inhibiting purine synthesis of peripheral blood mononuclear cells (PBMCs) in vitro by a mitogen assay procedure. PBMCs were obtained from 18… CONTINUE READING

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