Immunosuppressive effect of murine cytomegalovirus.

  title={Immunosuppressive effect of murine cytomegalovirus.},
  author={L. S. Loh and James Bradley Hudson},
  journal={Infection and immunity},
  volume={27 1},
Murine cytomegalovirus suppressed the ability of spleen cells to respond to mitogens in vitro. The degree of suppression was proportional to the multiplicity of infection. This effect could not be explained by cytolysis of lymphocytes, an alteration in the kinetics of the response to mitogen, or a direct competition between virions and mitogen molecules for cell-surface receptors. Nor was it due to simple contact between cell and virus, since ultraviolet-inactivated murine cytomegalovirus… CONTINUE READING