Immunosuppressive drugs: the first 50 years and a glance forward.

  title={Immunosuppressive drugs: the first 50 years and a glance forward.},
  author={Anthony C. Allison},
  volume={47 2-3},
During the past 50 years, many immunosuppressive drugs have been described. Often their mechanisms of action were established long after their discovery. Eventually these mechanisms were found to fall into five groups: (i) regulators of gene expression; (ii) alkylating agents; (iii) inhibitors of de novo purine synthesis; (iv) inhibitors of de novo pyrimidine synthesis; and (v) inhibitors of kinases and phosphatases. Glucocorticoids exert immunosuppressive and anti-inflammatory activity mainly… CONTINUE READING


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