Immunosuppressive components from an Ascomycete, Diplogelasinospora grovesii.

  title={Immunosuppressive components from an Ascomycete, Diplogelasinospora grovesii.},
  author={H. Fujimoto and J. Nagano and K. Yamaguchi and M. Yamazaki},
  journal={Chemical & pharmaceutical bulletin},
  volume={46 3},
  • H. Fujimoto, J. Nagano, +1 author M. Yamazaki
  • Published 1998
  • Medicine, Chemistry
  • Chemical & pharmaceutical bulletin
  • Two known fungal metabolites, macrophin and colletodiol, and a new stereoisomer of colletodiol named 10-epi-colletodiol, were isolated as immunosuppressive principles from an Ascomycete, Diplogelasinospora grovesii. The IC50 values of the major active component among them, macrophin, were calculated to be 0.4 and 0.3 microgram/ml against concanavalin A- and lipopolysaccharide-induced proliferations of mouse spleen lymphocytes, respectively. A new natural product, 4,8-dimethyl-1,5… CONTINUE READING
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