Immunosuppressive and postoperative effects of orthotopic liver transplantation on bone metabolism.

@article{Guichelaar2004ImmunosuppressiveAP,
  title={Immunosuppressive and postoperative effects of orthotopic liver transplantation on bone metabolism.},
  author={Maureen M J Guichelaar and Michael M Malinchoc and Jean D. Sibonga and Bart L Clarke and J Eileen Hay},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  year={2004},
  volume={10 5},
  pages={638-47}
}
Bone loss occurs early after orthotopic liver transplantation (OLT) in all liver transplant recipients and leads to postoperative fractures, especially in cholestatic patients with the lowest bone mass. Little is known about the underlying changes in bone metabolism after OLT or about the etiology of these changes. Histomorphometric analysis of bone biopsies, a method that allows assessment of bone volume, resorption, and formation, has shown improved bone metabolism at 4 months after OLT. It… CONTINUE READING

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