Immunosuppressive activity of the Chinese medicinal plant Tripterygium wilfordii. II. Prolongation of hamster-to-rat cardiac xenograft survival by combination therapy with the PG27 extract and cyclosporine.

@article{Wang2000ImmunosuppressiveAO,
  title={Immunosuppressive activity of the Chinese medicinal plant Tripterygium wilfordii. II. Prolongation of hamster-to-rat cardiac xenograft survival by combination therapy with the PG27 extract and cyclosporine.},
  author={Jing Wang and Rensheng Xu and Renling Jin and Zhenqing Chen and John M. Fidler},
  journal={Transplantation},
  year={2000},
  volume={70 3},
  pages={456-64}
}
BACKGROUND PG27 is an immunosuppressive fraction purified from an extract of a Chinese medicinal plant Tripterygium wilfordii, which we investigated alone and in combination with cyclosporine (CsA) in a concordant, hamster-to-rat cardiac xenotransplantation model. METHODS Golden Syrian hamster hearts were heterotopically transplanted into the abdomen of Lewis rat recipients, which were treated intraperitoneally or orally with PG27, CsA, or both. RESULTS Combination therapy with 30 mg/kg(day… CONTINUE READING