Corpus ID: 40266407

Immunosuppressive activity of some peptides related to cycloamanide A (CyA A) and to the active fragment of a peptide immunomodulator from ovine colostrum.

@article{BolewskaPedyczak1993ImmunosuppressiveAO,
  title={Immunosuppressive activity of some peptides related to cycloamanide A (CyA A) and to the active fragment of a peptide immunomodulator from ovine colostrum.},
  author={Eleonora Bolewska-Pedyczak and Zbigniew Wieczorek and Michakl Zimecki and Ignacy Z. Siemion},
  journal={Archivum immunologiae et therapiae experimentalis},
  year={1993},
  volume={41 5-6},
  pages={
          297-301
        }
}
A series of linear and cyclic hexapeptides, consisting of: Phe-Phe-Val-Pro-Gly-Ala, Tyr-Phe-Val-Pro-Gly-Ala, Phe-Tyr-Val-Pro-Gly-Ala, D-Phe-Tyr-Val-Pro-Gly-Ala, D-Tyr-Phe-Val-Pro-Gly-Ala, D-Tyr-Tyr-Val-Pro-Gly-Ala, c-(Phe-Tyr-Val-Pro-Gly-Ala-), c-(Tyr-Tyr-Val-Pro-Gly-Ala-) was synthesized and examined for the influence on humoral immune response by the plaque forming cell test. The peptides are related to Tyr-Val-Pro-Gly-Phe-Pro hexapeptide (an active fragment of immunomodulatory polypeptide… Expand
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Cyclolinopeptides and their analogs--a new family of peptide immunosuppressants affecting the calcineurin system.
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The results of the investigation of immunosuppressive activity of cyclolinopeptide A (CLA--cyclic hydrophobic nonapeptide present in the linseeds) and its analogs are discussed and it results that the molecular mechanism of the CLA action is the same as that of cyclosporin A and FK-506 compound. Expand
Medical and Biotechnological Aspects
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This chapter discusses the cycloamanide family of ribosomally biosynthesized cyclic peptides found, to date, only in some species of Amanita, Lepiota, and Galerina, with the emphasis on the amatoxins. Expand