Immunosuppressive activity of serum from liver-grafted rats: in vitro specific inhibition of mixed lymphocyte reactivity by antibodies against class II RT1 alloantigens.

@article{Tsurufuji1987ImmunosuppressiveAO,
  title={Immunosuppressive activity of serum from liver-grafted rats: in vitro specific inhibition of mixed lymphocyte reactivity by antibodies against class II RT1 alloantigens.},
  author={Makoto Tsurufuji and Kimiko Ishiguro and Takashi Shinomiya and Takafumi Uchida and Naoshi Kamada},
  journal={Immunology},
  year={1987},
  volume={61 4},
  pages={421-8}
}
The immunosuppressive activity of serum from PVG rats following orthotopic transplantation of DA liver has been examined in vitro. Liver grafts in this combination are never rejected, but induce a state of specific transplantation tolerance in the recipient. Serum from such tolerant animals was able to inhibit proliferation of normal PVG lymph node cells in response to DA stimulators in the mixed lymphocyte reaction (MLR); inhibition was specific for donor (DA) antigens. Interleukin-2 (IL-2… CONTINUE READING