Immunosuppressive activity of a subline of the mouse EL-4 lymphoma. Evidence for minute virus of mice causing the inhibition

@article{Bonnard1976ImmunosuppressiveAO,
  title={Immunosuppressive activity of a subline of the mouse EL-4 lymphoma. Evidence for minute virus of mice causing the inhibition},
  author={Guy D. Bonnard and Ernest Kelvin Manders and Donald A. Campbell and Ronald B. Herberman and Matthew J Collins},
  journal={The Journal of Experimental Medicine},
  year={1976},
  volume={143},
  pages={187 - 205}
}
Filtered culture fluids from the early in vitro passages of a subline of the C57BL/6 mouse EL-4 lymphoma, EL-4(G-), were strongly inhibitory for BABL/c vs. C57BL/6 mixed lymphocyte cultures (MLC). The inhibitory activity could be preserved by storage at -75 degrees C or 4 degrees C, thus allowing its further characterization. The inhibitory factor was particulate (nondialyzable, sedimentable at 100,000 g for 1 h), very small (recovered after 0.10 mum filtration), sensitive to UV irradiation… CONTINUE READING

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