Immunosuppression with Tacrolimus Improved Reproductive Outcome of Women with Repeated Implantation Failure and Elevated Peripheral Blood Th1/Th2 Cell Ratios

@article{Nakagawa2015ImmunosuppressionWT,
  title={Immunosuppression with Tacrolimus Improved Reproductive Outcome of Women with Repeated Implantation Failure and Elevated Peripheral Blood Th1/Th2 Cell Ratios},
  author={Koji Nakagawa and Joanne Kwak‐Kim and Kuniaki Ota and Keiji Kuroda and Michi Hisano and Rikikazu Sugiyama and Koushi Yamaguchi},
  journal={American Journal of Reproductive Immunology},
  year={2015},
  volume={73},
  pages={353 - 361}
}
We evaluated the clinical efficacy of immunosuppressive treatment with tacrolimus for repeated implantation failure (RIF) patients who have elevated in T helper (Th1)/Th2 cytokine producing cell ratios. 
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Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures
We aim to investigate whether the peripheral blood T helper (Th) 1 cell level could predict pregnancy outcome in patients who have experienced repeated implantation failure (RIF, three or more) after…
Increasing number of implantation failures and pregnancy losses associated with elevated Th1/Th2 cell ratio
TLDR
A high Th1/Th2 cell ratio was linked to ≥4 implantation failure cycles and ≥2 pregnancy losses were but not to general infertility.
Tacrolimus Improves the Implantation Rate in Patients with Elevated Th1/2 Helper Cell Ratio and Repeated Implantation Failure (RIF)
TLDR
The findings suggest that RIF patients with a higher Th1/Th2 ratio could be candidates for tacrolimus therapy and that this immunosuppressive drug could be acting through upregulation of LIF, IL-10, and IL-17.
Potential impact of maternal vitamin D status on peripheral blood and endometrium cellular immunity in women with recurrent implantation failure
This study aims to evaluate the modulatory effects of vitamin D on peripheral blood and endometrial cellular immunity in women with recurrent implantation failure (RIF).
Novel approaches to the management of recurrent pregnancy loss: The OPTIMUM (OPtimization of Thyroid function, Thrombophilia, Immunity, and Uterine Milieu) treatment strategy
Does the OPtimization of Thyroid function, Thrombophilia, Immunity, and Uterine Milieu (OPTIMUM) treatment strategy, developed for treating repeated implantation failure (RIF), contribute to…
The Impact of New Immunological Therapeutic Strategies on Recurrent Miscarriage and Recurrent Implantation Failure.
Successful treatment with intrauterine delivery of dexamethasone for repeated implantation failure
TLDR
Effective therapy for endometrial receptivity of patients with repeated embryo implantation failure (RIF) is far undeveloped and whether intrauterine perfusion of dexamethasone (DXM), local administration of drugs with less systematic side‐effects, and suppressing uterine NK (uNK) cells to improve endometrian receptivity remains unknown.
Analysis of the risk factors and treatment for repeated implantation failure: OPtimization of Thyroid function, IMmunity, and Uterine Milieu (OPTIMUM) treatment strategy
What are the pregnancy outcomes after the OPtimization of Thyroid function, Immunity, and Uterine Milieu (OPTIMUM) treatment strategy in patients with repeated implantation failure (RIF)?
Obstetric and perinatal outcome of the women with repeated implantation failures or recurrent pregnancy losses who received pre‐ and post‐conception tacrolimus treatment
TLDR
The clinical efficacy of tacrolimus in women with repeated implantation failures (RIF) of immune etiologies and its safety for women with RIF undergoing assisted reproductive technology cycles and their babies is reported.
Alteration in endometrial helper T‐cell subgroups in chronic endometritis
The effect of chronic endometritis (CE) on the subpopulation of CD4+ T cells, Th1, Th2, Th17, and regulatory T cells in the endometrium is unknown.
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TLDR
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