Immunosuppression-induced bronchial epithelial-mesenchymal transition: a potential contributor to obliterative bronchiolitis.

  title={Immunosuppression-induced bronchial epithelial-mesenchymal transition: a potential contributor to obliterative bronchiolitis.},
  author={Valerie M Felton and Landon J. Inge and B Cicero Willis and Ross M Bremner and Michael A. Smith},
  journal={The Journal of thoracic and cardiovascular surgery},
  volume={141 2},
OBJECTIVE Obliterative bronchiolitis is the predominant histopathologic finding in patients with chronic rejection after lung transplant. This fibroproliferative transformation within small airways of lung allograft is poorly understood; however, studies suggest epithelial-mesenchymal transition plays a role. Transplant immunosuppressive therapy has been shown to cause epithelial-mesenchymal transition in renal tubular epithelial cells, with subsequent fibrosis. This study explored whether… CONTINUE READING


Publications citing this paper.
Showing 1-6 of 6 extracted citations

Impact of the severity of acute rejection in the early phase after rat lung transplantation on the effectiveness of mycophenolate mofetil to treat chronic allograft rejection.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery • 2012
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 29 references

Epithelial repair mechanisms in the lung.

American journal of physiology. Lung cellular and molecular physiology • 2010
View 7 Excerpts
Highly Influenced

Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2009
View 6 Excerpts
Highly Influenced

Transforming growth factor beta (TGF-beta) and obliterative bronchiolitis following pulmonary transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation • 1999
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…