Immunosuppression in the definitive and intermediate hosts of the human parasite Schistosoma mansoni by release of immunoactive neuropeptides.

@article{DuvauxMiret1992ImmunosuppressionIT,
  title={Immunosuppression in the definitive and intermediate hosts of the human parasite Schistosoma mansoni by release of immunoactive neuropeptides.},
  author={O Duvaux-Miret and G B Stefano and Eric M. Smith and Colette Dissous and Andr{\'e} Capron},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 2},
  pages={778-81}
}
Evidence supporting the concept that the parasitic trematode Schistosoma mansoni may escape immune reactions from its vertebrate (man) or invertebrate (the freshwater snail Biomphalaria glabrata) hosts by using signal molecules it has in common with these hosts was obtained by the following experiments. The presence of immunoactive proopiomelanocortin (POMC)-derived peptides [corticotropin (ACTH), beta-endorphin] in, and their release from, S. mansoni was demonstrated. Coincubation of adult… CONTINUE READING
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