Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide.

@article{Grossman2011ImmunosuppressionIP,
  title={Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide.},
  author={Stuart Grossman and Xiaobu Ye and Glenn Jay Lesser and Andrew Sloan and Hetty E. Carraway and Serena Desideri and Steven Piantadosi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 16},
  pages={5473-80}
}
PURPOSE Patients with high-grade gliomas (HGG) routinely receive radiation, temozolomide, and glucocorticoids. As each of these is immunosuppressive, we conducted a prospective, multicenter study to follow CD4 counts over time and determine whether low CD4 counts were associated with adverse outcomes. EXPERIMENTAL DESIGN Patients with newly diagnosed HGG had CD4 counts drawn before initiating standard therapy and monthly thereafter for 1 year. Information on hospitalizations, infections… CONTINUE READING