Immunosuppression in melanoma immunotherapy: potential opportunities for intervention.

  title={Immunosuppression in melanoma immunotherapy: potential opportunities for intervention.},
  author={Gregory A. Lizee and Laszlo G. Radvanyi and Willem W. Overwijk and Patrick Hwu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={12 7 Pt 2},
Although melanomas are substantially more immunogenic than other tumors, current immunotherapeutic approaches for melanoma patients have met with only limited success. Although melanoma-specific CD8+ T-cell responses can often be generated in patients naturally or through vaccination regimens, tumors frequently continue to grow unabated, suggesting that tumor-specific immune responses may be actively dampened in vivo. Research over the past decade has brought to light several mechanisms used by… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 18 extracted citations


Publications referenced by this paper.
Showing 1-10 of 78 references

Co - inhibitory role of Tcellassociated B 7H 1 and B 7DC in theTcell immune response

  • SK Seo, HM Seo
  • Immunol Lett
  • 2006

HumanTcell responses againstmelanoma

  • T Boon, PG Coulie, BJ Van den Eynde, P. Van der Bruggen
  • Annu Rev Immunol
  • 2006

IL - 2 administration increases CD 4 + CD 25 ( hi ) Foxp 3 + regulatory Tcells in cancer patients

  • AhmadzadehM, SA Rosenberg
  • Blood
  • 2006

Restoring function in exhausted CD 8 Tcells during chronic viral infection

  • DL Barber, EJ Wherry, D Masopust
  • Nature
  • 2006

Role of immaturemyeloid cells inmechanisms of immune evasion in cancer

  • S Kusmartsev, DI Gabrilovich
  • Cancer Immunol Immunother
  • 2006

Similar Papers

Loading similar papers…