Immunosuppression in malaria: effect of hemozoin produced by Plasmodium berghei and Plasmodium falciparum.

Abstract

To a considerable degree, malaria-induced immunosuppression has been attributed to an inhibition of macrophage accessory cell function. In this study hemozoin, a plasmodium hemoglobin degradation product which readily accumulates in phagocytic cells and tissues during infection, was examined for its influence on immune responses. Hemozoin-laden liver and… (More)

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