Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugs.

@article{Crescioli2008ImmunosuppressionIC,
  title={Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugs.},
  author={Clara Crescioli and Roberta Squecco and Lorenzo Cosmi and Mariangela Sottili and Stefania Gelmini and Elisa Borgogni and Erica Sarchielli and Sabino Scolletta and Fabio Francini and Francesco Annunziato and Gabriella Barbara Vannelli and M. Kerala Serio},
  journal={Experimental cell research},
  year={2008},
  volume={314 6},
  pages={1337-50}
}
CXCL10-CXCR3 axis plays a pivotal role in cardiac allograft rejection, so that targeting CXCL10 without inducing generalized immunosuppression may be of therapeutic significance in allotransplantation. Since the role of resident cells in cardiac rejection is still unclear, we aimed to establish reliable human cardiomyocyte cultures to investigate Th1 cytokine-mediated response in allograft rejection. We used human fetal cardiomyocytes (Hfcm) isolated from fetal hearts, obtained after legal… CONTINUE READING