Immunosuppression for liver transplantation in HCV-infected patients: mechanism-based principles.

@article{Eghtesad2005ImmunosuppressionFL,
  title={Immunosuppression for liver transplantation in HCV-infected patients: mechanism-based principles.},
  author={Bijan Eghtesad and John J. Fung and Anthony Jack Demetris and Noriko Murase and Roberta Ness and Debra C. Bass and Edward A. Gray and Obaid Shakil and Bridget Flynn and Amadeo Marcos and Thomas E. Starzl},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  year={2005},
  volume={11 11},
  pages={1343-52}
}
We retrospectively analyzed 42 hepatitis C virus (HCV)-infected patients who underwent cadaveric liver transplantation under two strategies of immunosuppression: (1) daily tacrolimus (TAC) throughout and an initial cycle of high-dose prednisone (PRED) with subsequent gradual steroid weaning, or (2) intraoperative antithymocyte globulin (ATG) and daily TAC that was later space weaned. After 36 +/- 4 months, patient and graft survival in the first group was 18/19 (94.7%) with no examples of… CONTINUE READING
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