• Corpus ID: 36204201

Immunosuppression by sex steroid hormones. The effect upon PHA- and PPD-stimulated lymphocytes.

  title={Immunosuppression by sex steroid hormones. The effect upon PHA- and PPD-stimulated lymphocytes.},
  author={Frederic A. Wyle and John R. Kent},
  journal={Clinical and experimental immunology},
  volume={27 3},
  • F. Wyle, J. Kent
  • Published 1 March 1977
  • Biology, Medicine
  • Clinical and experimental immunology
Progesterone, estradiol, testosterone, cortisol, and 11-desoxycortisol (compound S) were added to cultures of human lymphocytes stimulated with phytohaemagglutinin (PHA) and purified protein derivative (PPD). The immunosuppressive effect of cortisol was verified and the three sex-steroid hormones also were found to inhibit lymphocyte transformation although at concentrations higher than for cortisol. Compound S, a steroid of low biological potency, also had immunosuppressive activity. At… 
Studies on the immunosuppressive role of steroid hormones during pregnancy.
The suppressive effect of pregnancy serum was found to have no correlation with its steroid content, and steroids did not seem to affect the maternal immune system as evidenced by the present study.
The effects of steroids on phytohaemagglutin-induced lymphoblastogenesis.
Anabolic androgenic steroids effects on the immune system: a review
Several common AAS have been shown to adversely influence lymphocyte differentiation and proliferation, antibody production, Natural Killer Cytotoxic activity and the production of certain cytokines, thereby altering the immune reaction.
Effects of testosterone, oestradiol and progesterone on immune regulation.
The in vitro effects of testosterone, oestradiol and progesterone on selected aspects of immune regulation were studied in normal adults to suggest that certain endocrine changes may alter immunoregulatory function and account for some of the clinical observations previously noted in diseases associated with defects of immuneregulation.
Steroids as Immunosuppressants in Pregnancy
The results suggest, but do not prove, that progesterone does not act on immune cells by binding to the glucocorticoid receptor, which can be considered to be advantageous, for otherwise pregnancy could be associated with glucoc Corticoid toxicity.
Effect of Testosterone and Estradiol on T and B Cell Responses in P W M Cultures
The effect of estradiol and testosterone on human blood lymphocytes in pokeweed mitogen (PWM)l-stimulated cultures is studied and it is found that addition of physiological concentrations ofestradiol to PWM cultures enhanced the B cell differentiation without affecting the proliferative response.
Sex hormones and immune dysregulation in multiple myeloma
Evidence is provided for two different patterns of sex hormone changes and immune dysfunctions presented differently by male and female multiple myeloma patients, which could be responsible for the immune dysfunction observed in multipleMyeloma.