• Corpus ID: 36204201

Immunosuppression by sex steroid hormones. The effect upon PHA- and PPD-stimulated lymphocytes.

@article{Wyle1977ImmunosuppressionBS,
  title={Immunosuppression by sex steroid hormones. The effect upon PHA- and PPD-stimulated lymphocytes.},
  author={Frederic A. Wyle and John R. Kent},
  journal={Clinical and experimental immunology},
  year={1977},
  volume={27 3},
  pages={
          407-15
        }
}
  • F. Wyle, J. Kent
  • Published 1 March 1977
  • Biology, Medicine
  • Clinical and experimental immunology
Progesterone, estradiol, testosterone, cortisol, and 11-desoxycortisol (compound S) were added to cultures of human lymphocytes stimulated with phytohaemagglutinin (PHA) and purified protein derivative (PPD). The immunosuppressive effect of cortisol was verified and the three sex-steroid hormones also were found to inhibit lymphocyte transformation although at concentrations higher than for cortisol. Compound S, a steroid of low biological potency, also had immunosuppressive activity. At… 
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