Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications

  title={Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications},
  author={Soufiane Ghannam and Carine Bouffi and Farida Djouad and Christian Jorgensen and Dani{\'e}le No{\"e}l},
  booktitle={Stem Cell Research & Therapy},
Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitor cells that are isolated from many adult tissues, in particular from the bone marrow and adipose tissue. Along with their capacity for differentiating into cells of mesodermal lineage, such as adipocytes, osteoblasts and chondrocytes, these cells have also generated great interest for their ability to display immunomodulatory capacities. Indeed, a major breakthrough came with the finding that they are able to induce… CONTINUE READING
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