Immunosuppression by D-isomers of HLA class I heavy chain (amino acid 75 to 84)-derived peptides is independent of binding to HSC70.

@article{Woo1997ImmunosuppressionBD,
  title={Immunosuppression by D-isomers of HLA class I heavy chain (amino acid 75 to 84)-derived peptides is independent of binding to HSC70.},
  author={Jacky Woo and Suhasini Iyer and Miguel Cornejo and L Gao and Cristina Cuturi and Jean Paul Soulillou and Roland Buelow},
  journal={Transplantation},
  year={1997},
  volume={64 10},
  pages={1460-7}
}
BACKGROUND Peptides derived from the class I heavy chain were shown to modulate immune responses in vitro and in vivo. A peptide derived from HLA-B2702 (2702.75-84) inhibited differentiation of cytotoxic T cells as well as T cell and natural killer cell-mediated cytotoxicity in vitro. Peptide-mediated immunomodulation seemed to be independent of the MHC proteins expressed by responder and stimulator cells. In vivo studies in rodents demonstrated prolongation of heart and skin allograft survival… CONTINUE READING

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