Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.

@article{Bodmer1989ImmunosuppressionAT,
  title={Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.},
  author={Stefan Bodmer and K N Strommer and Karl Frei and Christine Siepl and Nicolas de Tribolet and Irina Heid and Adriano Fontana},
  journal={Journal of immunology},
  year={1989},
  volume={143 10},
  pages={3222-9}
}
Transforming growth factor (TGF)-beta 1 is a polypeptide that is assumed to play a fundamental role in the growth of both normal and neoplastic cells. TGF-beta 2 is a closely related polypeptide, originally described as glioblastoma cell-derived T cell suppressor factor (G-TsF) due to its immunosuppressive activity. Expression of the genes for TGF-beta 1 and G-TsF/TGF-beta 2 was examined in tumor cells and was found to be different in several cell lines and tissues that were tested. Whereas two… CONTINUE READING
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