Immunosuppression and risk of cervical cancer
@article{Dugu2013ImmunosuppressionAR, title={Immunosuppression and risk of cervical cancer}, author={Pierre-Antoine Dugu{\'e} and Matejka Rebolj and Peter Garred and Elsebeth Lynge}, journal={Expert Review of Anticancer Therapy}, year={2013}, volume={13}, pages={29 - 42} }
A markedly increased risk of cervical cancer is known in women immunosuppressed due to AIDS or therapy following organ transplantation. The aim of this review is to determine the association between other conditions affecting the immune system and the risk of cervical cancer. Patients with end-stage renal disease seem to be at an increased risk of cervical cancer. A higher risk of cervical precancerous lesions was found in patients with some autoimmune diseases; particularly if treated with…
65 Citations
Risk of cervical cancer in women with autoimmune diseases, in relation with their use of immunosuppressants and screening: Population‐based cohort study
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Although most patients with AIDs do not have an increased risk of cervical cancer, those taking substantial amounts of azathioprine might need more stringent cervical screening measures.
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Screening guidelines have been developed or advocated for processes that have detectable premalignant lesions, such as anal cancer or cervical cancer, and diagnosis relies on cytologic, histologic, or molecular methods.
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It is suggested that women exposed to secondhand smoking at home or in the workplace might be at high risk of HR-HPV persistence when it is combined with alcohol drinking, even though neither active smoking nor second hand smoking independently affects the risk.
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- MedicineAIDS
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HIV-positive women have higher risk of acquiring HPV, with risk inversely associated with CD4+ cell count, and ART lowered HPV acquisition, increased clearance, and reduced precancer progression, likely via immune reconstitution.
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- MedicineBioMed research international
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Data so far are not robust enough to justify a correlation between immunodeficiency and multiple primary malignancies in transplanted patients, as they are at higher risk of developing cancer due to the chronic assumption of immunosuppression.
Risks of female genital tract related cancers (gynecological cancers) or breast cancer in women with and without chronic kidney disease
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The hypothesis that the risk of female genital tract related cancer (gynecological cancer: GC) or breast cancer (BC) of women with chronic kidney disease (CKD) might be different from that of those women without CKD is tested.
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