Immunosuppression and risk of cervical cancer

@article{Dugu2013ImmunosuppressionAR,
  title={Immunosuppression and risk of cervical cancer},
  author={Pierre-Antoine Dugu{\'e} and Matejka Rebolj and Peter Garred and Elsebeth Lynge},
  journal={Expert Review of Anticancer Therapy},
  year={2013},
  volume={13},
  pages={29 - 42}
}
A markedly increased risk of cervical cancer is known in women immunosuppressed due to AIDS or therapy following organ transplantation. The aim of this review is to determine the association between other conditions affecting the immune system and the risk of cervical cancer. Patients with end-stage renal disease seem to be at an increased risk of cervical cancer. A higher risk of cervical precancerous lesions was found in patients with some autoimmune diseases; particularly if treated with… 
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65 Citations
Highly Influential Citations
5
Background Citations
26
Methods Citations
1

65 Citations

Risk of cervical cancer in women with autoimmune diseases, in relation with their use of immunosuppressants and screening: Population‐based cohort study
TLDR
Although most patients with AIDs do not have an increased risk of cervical cancer, those taking substantial amounts of azathioprine might need more stringent cervical screening measures.
Human Papillomavirus.
TLDR
Screening guidelines have been developed or advocated for processes that have detectable premalignant lesions, such as anal cancer or cervical cancer, and diagnosis relies on cytologic, histologic, or molecular methods.
Advancements in Cervical Cancer Prevention and Management of Persistent, Recurrent, and Metastatic Disease: 2016 Update
TLDR
Current and emerging therapies in locally advanced, recurrent, and metastatic cervical cancer and their role in clinical practice are reviewed, including bevacizumab to combination chemotherapy showed a 3.7-month advantage in OS in 2014.
Chlamydia trachomatis and risk of cervical intraepithelial neoplasia grade 3 or worse in women with persistent human papillomavirus infection: a cohort study
TLDR
Repeated CT infections increased the risk of CIN3+ among women with prevalent as well as persistent high-risk HPV infection.
Combined Effect of Secondhand Smoking and Alcohol Drinking on Risk of Persistent Human Papillomavirus Infection
TLDR
It is suggested that women exposed to secondhand smoking at home or in the workplace might be at high risk of HR-HPV persistence when it is combined with alcohol drinking, even though neither active smoking nor second hand smoking independently affects the risk.
HIV-positive women have higher risk of human papilloma virus infection, precancerous lesions, and cervical cancer
TLDR
HIV-positive women have higher risk of acquiring HPV, with risk inversely associated with CD4+ cell count, and ART lowered HPV acquisition, increased clearance, and reduced precancer progression, likely via immune reconstitution.
Eliminating Cervical Cancer in Mali and Senegal, Two Sub-Saharan Countries: Insights and Optimizing Solutions
TLDR
It is proposed that screening by visual inspection with acetic acid accompanied by self-sampling is the most cost-effective, culturally acceptable and most feasible strategy to implement in primary care settings and HPV DNA testing would be affordable, if local laboratory facilities could be established.
Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study
TLDR
Data so far are not robust enough to justify a correlation between immunodeficiency and multiple primary malignancies in transplanted patients, as they are at higher risk of developing cancer due to the chronic assumption of immunosuppression.
Risks of female genital tract related cancers (gynecological cancers) or breast cancer in women with and without chronic kidney disease
TLDR
The hypothesis that the risk of female genital tract related cancer (gynecological cancer: GC) or breast cancer (BC) of women with chronic kidney disease (CKD) might be different from that of those women without CKD is tested.
Considerations for Child Cancer Survivors and Immunocompromised Children to Prevent Secondary HPV-associated Cancers.
TLDR
The epidemiology of vaccine efficacy, the natural history of HPV infections, and accelerated HPV-associated cancer development in populations at high risk for the development of secondary Human Papillomavirus (HPV)-associated cancers are examined.
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