Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.

@article{Linke2001ImmunosuppressedSP,
  title={Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.},
  author={Michael Linke and Chad E. Harris and Thomas R. Korfhagen and Francis X McCormack and Alan Ashbaugh and Peter Steele and Jeffery A Whitsett and Peter D. Walzer},
  journal={The Journal of infectious diseases},
  year={2001},
  volume={183 6},
  pages={943-52}
}
Immunosuppressed Swiss Black mice deficient in surfactant protein A (SP-A(-/-)) and wild-type control mice (SP-A(+/+)) were exposed to Pneumocystis carinii by environmental exposure, intratracheal inoculation, and direct exposure to other infected animals. The frequency and intensity of P. carinii infection were significantly greater in the SP-A(-/-) mice by all 3 methods of exposure. P. carinii free of SP-A and alveolar macrophages were isolated from SP-A(-/-) mice and were tested in an in… CONTINUE READING

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