Immunosuppressant MPA Modulates Tight Junction through Epigenetic Activation of MLCK/MLC-2 Pathway via p38MAPK

@inproceedings{Khan2015ImmunosuppressantMM,
  title={Immunosuppressant MPA Modulates Tight Junction through Epigenetic Activation of MLCK/MLC-2 Pathway via p38MAPK},
  author={Niamat Khan and Dasaradha Venkata Krishna Pantakani and Lutz Binder and Muhammad Qasim and Abdul R Asif},
  booktitle={Front. Physiol.},
  year={2015}
}
BACKGROUND Mycophenolic acid (MPA) is an important immunosuppressive drug (ISD) prescribed to prevent graft rejection in the organ transplanted patients, however, its use is also associated with adverse side effects like sporadic gastrointestinal (GI) disturbances. Recently, we reported the MPA induced tight junctions (TJs) deregulation which involves MLCK/MLC-2 pathway. Here, we investigated the global histone acetylation as well as gene-specific chromatin signature of several genes associated… CONTINUE READING
3
Twitter Mentions

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-6 OF 6 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 65 REFERENCES

Multifunctional strands in tight junctions

  • Nature Reviews Molecular Cell Biology
  • 2001
VIEW 16 EXCERPTS
HIGHLY INFLUENTIAL

Changes in the small bowel of symptomatic kidney

Kuo, T H.
  • 2014