Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

@article{Dawson1993ImmunosuppressantFE,
  title={Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.},
  author={Ted M Dawson and Joseph P. Steiner and Valina L Dawson and Jay L Dinerman and George R. Uhl and Solomon H Snyder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 21},
  pages={9808-12}
}
Immunosuppressants FK506 and cyclosporin A inhibit neurotoxicity of N-methyl-D-aspartate in primary cortical cultures, while having no effect on quisqualate- and kainate-mediated neurotoxicity. Rapamycin completely reverses the neuroprotective effect of FK506. Both FK506 and cyclosporin A inhibit NMDA-elicited/nitric oxide-mediated increases in cGMP levels in cortical cultures. FK506 has no effect on sodium nitroprusside-induced increases in cGMP. In a stably transfected human kidney 293 cell… CONTINUE READING