Immunostructural evidence for the template mechanism of microtubule nucleation

  title={Immunostructural evidence for the template mechanism of microtubule nucleation},
  author={Thomas J. Keating and Gary G. Borisy},
  journal={Nature Cell Biology},
Two opposing models have been proposed to explain how the γ-tubulin ring complex (γTuRC) induces microtubule nucleation. In the ‘protofilament’ model, the γTuRC induces nucleation as a partially or completely straightened protofilament that is incorporated longitudinally into the wall of the nascent microtubule, whereas the ‘template’ model proposes that the γTuRC acts as a helical template that constitutes the base of the newly-formed polymer. Here we appraise these two models, using high… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 52 extracted citations

A novel pollen-specific α-tubulin in sunflower: structure and characterization

Plant Molecular Biology • 2004
View 4 Excerpts
Highly Influenced

Emergent Properties of the Metaphase Spindle.

Cold Spring Harbor perspectives in biology • 2015


Publications referenced by this paper.
Showing 1-10 of 37 references

Characterization of two related Drosophila γ-tubulin complexes that differ in their ability to nucleate microtubules

K Oegema
J. Cell Biol. 144, • 1999

Similar Papers

Loading similar papers…