Immunostructural evidence for the template mechanism of microtubule nucleation

@article{Keating2000ImmunostructuralEF,
  title={Immunostructural evidence for the template mechanism of microtubule nucleation},
  author={Thomas J. Keating and Gary G. Borisy},
  journal={Nature Cell Biology},
  year={2000},
  volume={2},
  pages={352-357}
}
Two opposing models have been proposed to explain how the γ-tubulin ring complex (γTuRC) induces microtubule nucleation. In the ‘protofilament’ model, the γTuRC induces nucleation as a partially or completely straightened protofilament that is incorporated longitudinally into the wall of the nascent microtubule, whereas the ‘template’ model proposes that the γTuRC acts as a helical template that constitutes the base of the newly-formed polymer. Here we appraise these two models, using high… CONTINUE READING

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