Immunostimulatory oligonucleotides inhibit colonic proinflammatory cytokine production in ulcerative colitis.

BACKGROUND We previously showed that Toll-like receptor-9 (TLR-9) ligands ameliorate experimental colitis. In this study, we evaluated the effect of TLR-9 ligands on the generation of proinflammatory cytokines by human colonic mucosa. MATERIALS AND METHODS Colonoscopic biopsies were obtained from patients with active ulcerative colitis (UC) and from… CONTINUE READING