Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors

@inproceedings{Corsini2015ImmunostimulatoryEO,
  title={Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors},
  author={Emanuela Corsini and Valentina Galbiati and Antonella Pinto and Annalisa Davin and Letizia Polito and Antonio Guaita and Marco Racchi},
  booktitle={Oncotarget},
  year={2015}
}
Aims of this study were to investigate the ability of RACK1 pseudosubstrate alone or in combination with classical immune stimuli to activate human leukocytes, and to restore age-associated immune defects.A total of 25 donors (17 old donors, 77-79 yrs; 8 young donors, 25-34 yrs) were enrolled. To evaluate the effect of RACK1 pseudosubstrate on cytokine production and CD86 expression the whole blood assay was used. Cultures were treated with RACK1 pseudosubstrate in the presence or absence of… CONTINUE READING