Immunostimulatory DNA sequences influence the course of adjuvant arthritis.

  title={Immunostimulatory DNA sequences influence the course of adjuvant arthritis.},
  author={Arash Ronaghy and Berent Prakken and Kenji Takabayashi and Gary S. Firestein and David Boyle and Nathan J. Zvailfler and Sarah T.A. Roord and Salvatore Albani and Dennis Anthony Carson and Eyal Raz},
  journal={Journal of immunology},
  volume={168 1},
Bacterial DNA is enriched in unmethylated CpG motifs that have been shown to activate the innate immune system. These immunostimulatory DNA sequences (ISS) induce inflammation when injected directly into joints. However, the role of bacterial DNA in systemic arthritis is not known. The purpose of the present experiments was to determine whether ISS contributes to the development of adjuvant arthritis in Lewis rats after intradermal injection of heat-killed Mycobacterium tuberculosis (Mtb). The… CONTINUE READING