Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling.

@article{Cho2004ImmunostimulatoryDI,
  title={Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling.},
  author={Jae Youn Cho and Marina D Miller and Kwang Je Baek and Ji Won Han and Jyothi Nayar and M{\'o}nica Rodr{\'i}guez and Sook Young Lee and Kirsti McElwain and Shauna McElwain and Eyal Raz and David H. Broide},
  journal={American journal of respiratory cell and molecular biology},
  year={2004},
  volume={30 5},
  pages={651-61}
}
Immunostimulatory sequences of DNA (ISS) inhibit eosinophilic airway inflammation, Th2 responses, and airway hyperreactivity (AHR) in mouse models of acute ovalbumin (OVA)-induced airway inflammation. To determine whether ISS inhibits airway remodeling, we developed a mouse model of airway remodeling in which OVA-sensitized mice were repeatedly exposed to intranasal OVA administration for 1-6 mo. Mice chronically exposed to OVA developed sustained eosinophilic airway inflammation and sustained… CONTINUE READING